Peperomia pellucida uses for the plant vary. P. pellucida has been used for treating abdominal pain, abscesses, acne, boils, colic, fatigue, gout, headache, renal disorders, and rheumatic joint pain.
Peperomia pellucida has been used as a food item as well as a medicinal herb. Although mostly grown for its ornamental foliage, the entire plant is edible, both cooked and raw.